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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b7c4a3c7a0a291ef61ad3ded6c6db7b2b3057ba029adb73dc385e6667a53a365' 
  AND token = '2DeZ2r0SEmcVKrbq/0BTBC8zgiDVTR2J2io3sgi3TaA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}