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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f78d9d6303eaa31136a9001fd75b794d912e5d53ff57032e17380cd6d42d05e' 
  AND token = 'LON9OcoeH2MQRJY8FGs9GmeMP+EBlIxMvXMjnV9Xzk0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}