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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b00a03dd79aead4888f09f07e957117b01ede6748e6b27fbf0f72c95bc5d3d9' 
  AND token = '2w/ArXiGlrNbaEkWrR7A/dEL2xmTh7Bq2aMWDLFJHTA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}