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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49fe817c739a6066809cec0b6623918101da48e05c3daa36fb1cf25e258233a4' 
  AND token = '+vAMuBkE9d2+jCUD1Kbd+ZMxomPFQUlOERkO7iuhA0E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}