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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf529b964302f725b4fbcb6a4e98559cd91b6fa0044aee6adc898fe7e78239c0' 
  AND token = 'EWmUEiuXRE/cO/5UH5qlyVZmIfScxVIY/QUPds7KGi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}