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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c686d7579fb393e9a2d8b679451db3a35d5da9bb65aa89db6dc4d2de62d0cba' 
  AND token = 'l5gnUXIlyuE7aHODxsS8SntSSYC4ZBHvhghMz4yKkf8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}