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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27c89b8d7f2e40312922fc9ada411740043e17b199c4e60ec7dbb78cdd7c903b' 
  AND token = 'lwN8TfxEkoSyT+WUaGlF4zPuohZ6tJZJe+ICsKdTm58=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}