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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fd6fcef9949461be81473fb7750972eec3c1fe2d4628be25ab18c0f20d3a437' 
  AND token = '4H2tEObyg154Ra+ej8Yg94lIOdG8PoHhZQsh3aUHtc4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}