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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81d43575c09559f403b0b52272a1f0bda269b560976bac2378f183bafa625e05' 
  AND token = 'bf1qsyN6TfgSh0titzFvB+uH8lOFtRmoZxSz4LaqrzU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}