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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6efe22edfeccfea837708e2045ef27f6bd75e9d289ce06877c080251842b328a' 
  AND token = 'B751NYLUcD76AFFc1Y8TTkUEC8cB5f/1UxXWBEZjp90=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}