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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b18463f8ac08d0647ece8cac09d9fc2111919ac1d459d1460ea1fe39525af06' 
  AND token = 'wj3C1WU6TVeKD1ttIqrDkmBE1G0DvRgNeEW5GIDu45s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}