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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42a0bc0a6967c33df5d19f50a0741e41225aa264e31a9458b09157f378184d4e' 
  AND token = 'yP8VPTMofc3/+wEgQiiQrrrwDZP0BdDeA749LtmdUVs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}