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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e257e6fea22118357a4135d71eb3e6a9a5d5768eba07ab4dd03bb04376e4d8f' 
  AND token = 'H2w22ryn7hqtlLAtggTuTqgC478/2SQ7+70vjw/1qgc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}