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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d47ccdb94550f2e6816bd9ff41e702039f5df1aee2bc3e58bf2183566280978' 
  AND token = 'f4FXMT/D+cUsQyo9DG1ZKY4uLUbEoyaspVQ88e2ZwL8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}