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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d25b0c9a535f3bd9203b9ee0746a437a40de4adc6fedd900f488cc5852e4b48' 
  AND token = 'yaDuKVXnm2XF7oq5nAyq6bHUw9WUfmW5Q4kEsRMrhKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}