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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a8cb361a1d7d0a8593216651c1d290ff2a735c39fc29dc3843188b8b9e438aa' 
  AND token = 'DB2ST2aoHjAGHNUVwe3OvCToc4H0/Az7PdhjI6Y5hnY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}