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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ecdce12494567427ca0c91074d68330553b1749cd1a3ad0c1d41166b2651e67' 
  AND token = 'MP0uAVRHOeVF9NMUKjQc8J+SmlNEIsdM1YAc8HtsUpM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}