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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef65c7ab6464520277638a4ff02789cf7536d57b59d1c5ee20a908f1faf53b35' 
  AND token = 'FZW3E44GsKmJ9oH2+607y6/KoT+aEU73//nygKT6Zg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}