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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00de6d9dce8e2c126c8b899841b0495b7746e3ae9148873f4248bc6f10a50280' 
  AND token = 'r6oM6ygT5YKPfzH7t3rxUpCwZzWcc7gOVkgplBYgRDs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}