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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2297183af8978f230953d6e1646f36c013ebbeb8cfd54090f63ccba296a6a372' 
  AND token = 'M3Sb4H7FZOjUf0eKxIBh7U30DTwPYvQzY1XQf7JssPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}