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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a10b639a7127a760299a26d00d44d768318e1976e516c00fb37c4d6f913a156' 
  AND token = 'VqmMdhctc6G0amBYRQsE4ie+8u+PO3qpOcgQ1BcnJsU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}