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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849e225c2c7b5488d17c073081dbbc0a6ee72f07718000a15642fc0d89dcf66e' 
  AND token = 'MNeEO90vFPZUq+flsZUVYlG9yNWGUJBcGJVWyHcDaqo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}