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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22046c8fa0b4bc62d85218c07f7d44c5ebb2907de3a0e78c41b95b62ddf12efb' 
  AND token = 'dfXHThv/rF4EqOYXLR79HsSTP2ZESEC16IKmnJ9rGmk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}