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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '420aa4e1b17d5016b0cf0f89dfe62705699852544eb8b1428f16416427d3cec7' 
  AND token = 'Ern8v8ydRKNSxiY1fk0vmupoUQefHo18MysRZbPVaZY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}