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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4145dd0dc5ee55a50b236c81cc3c219ba38c94d7ac733339e72eba7de3b897f7' 
  AND token = 'wS5pBI4C45BCZp0P8Tub3tITGEOkFOGAy+4zlmsHTS8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}