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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b175dd6f0b20ebd807c8721181166829ea37d72e83bf9a425d4a977680f1413' 
  AND token = 'TJTtvPgo0L6RRcD0rrOXiDq8jmLFt0vup+WCJj3brSk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}