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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59d49e5b0fd76151304031ff9e96e2e732f94b6351f1dae9d51dbb709da40a8e' 
  AND token = 'EkVHj0uIGB8ZA24E/4NTFRHfU40rgFPZ6AHhAA0s4Jo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}