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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6221405eb4b2d0c82e3290f684ed06fbedcba52d377cad03e6b9a651b4cc73c0' 
  AND token = 'XkUqTr/drpNUrK2jciD9rm4Iu3w4MQ/6VvciLOD7S6w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}