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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3278e5632e1905c8e657568df850690f291d3f0df7510949a667ec7525dafac1' 
  AND token = 'ZLMrWDKBdjwp3oJjLW75bZdGRol6fUsOz0uEBmG1Qdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}