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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221cce7f794a1aeb9d51f3923b2a17f11c5a4224f853e6938efb2e6eb8050e1e' 
  AND token = 'wfLF22AZMCs0VBuXtM4wBjaDpPUA+d7DZjCKrYyBqf8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}