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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bb1b378d7211586ae873e6c48239914c61f87a5e8c9888c489a7688217dd41ab' 
  AND token = 'sghGUTIGfxnYapQp0RpyN2WKjMTZSjNCrDjvDA4xBnc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}