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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80ab1b7ce5645cace14a342b9535422433e4387815becb2f6cdb44f65b15d6c2' 
  AND token = 'mfWliGDJYrsrCwn2O3jG/F70bDLLZrOne2QEHtodGSc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}