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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ce91dc994b29b5fff5aeffbb2a64077bfcb98c7acbcab57d099b9225c5a572c' 
  AND token = 'nQtkVhgGtIzSTvvE2peTHuDGvfcVI3XDxMGo9/nfuOQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}