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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b7220e8a8a5a8604e672ee92325b8ef068ca10a63cfacda099cbd2a1482b38c6' 
  AND token = 'ykD9PVg5rPt7LaV5BTWV33xC4aQ0hqMbygfRSbXlOu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}