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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '101ad162d742437bade3457f4faf2f4bb024b73653af00469828c5730554cdd1' 
  AND token = 'TdtPkS0bSH6kRnjr9yBGA/uhoRVtQX7Mf1EN0eVSuRw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}