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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '746917e5964b4dc6be8e6f5f458eaea3e3d9949e439d839003015c089bca8d8a' 
  AND token = 'AzZNdJwY+rLr8aDn7VbGPUo1bPeS5JMh2pYAyumveLI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}