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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43b2d1268fd5bba8e4709d743dacd72a973c577811d0a1b20b27b2baf87d1173' 
  AND token = 'iREn7FQrvZ+Kmm2qNoz+GPbhu2JrsS2rpWFrjWoU7yM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}