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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e24403d85be4089fe2c41c9a921f9dce81f6e357438d409bd95f4c63194f3888' 
  AND token = 'dOhQA836AtZHWHrHwgbchW5bKfMTWgnh5voHDxQlFd8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}