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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59e59d2d8cac7419140afda888b19908c96a2e9df46e5538caef3aa4d0738aa4' 
  AND token = 'TtMYWpzV/Fmt/DqbFXzatOsK5vrckSVSv/LG+8UkM8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}