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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8808a2d8abc9216cd5493bccba5ee43ada23ef0d45f0848d4eea74d1bccd145' 
  AND token = 'sK5vNaL1FtdWVdLdLnw6YSdtsHxDw8LjoMZf92ZJg20=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}