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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54c1e95f58c3e98c93256c1d1268a4251abd596e55ba15b4f0581c6dc5dd7081' 
  AND token = 'uZ7ut+S5+saY6O5f1lXI7gmlXL1CKTPhP9RpjrIQdRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}