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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78c26772fc5c786a4709222d478cf9bc674846dd03f7596ee12505a075f6c238' 
  AND token = 'EkCdV1E2Own3sYXBjbDwphb0sdm1cWUPMhNF14uUS+c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}