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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3e490201683a8963d70cb7b950a3bbb157f1266334da14ad9ce590a17b0db22' 
  AND token = 'JMbqXkQQr3DJE5tcaz5I3apsal5F1aTxS0ahMGbuJkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}