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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '439a3c913eb331cfd07ce1c8fff66cb3ef7b598ef6b615cd141e0e9c51054473' 
  AND token = 'R2bNHwIZ4FHcXSMWNUUmaxelM6uvXwD1KoB1IZ26gpU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}