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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b50f57491a1dfbb909f6ad7868b10790cc28d857f8be6aedc72ca99c874f756f' 
  AND token = 'ZmA5/D0glAxrqvQSD61iFDMwMSiG2C6NvD+0PTLRr/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}