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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78297beb0c9879e3a0bb68d1aa1faa3166bfda6f3f53d93500a8bbe7976f910c' 
  AND token = 'jb3tZL7cxU7BTN6zKS9Jj74cxU3zrpdBvnwWpy+tn2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}