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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '157c052127fec5051501f9ca61e0f8dcf1bb57ed4f32ddc907156860b8e4b1b8' 
  AND token = 'pDSJ7VuBCwG7a6lpUjwG4ZBAhk2CcT1Thx0bBj/Lb0w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}