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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e53755d9e8f7df8d2c520a6264bbdfa65b41870c5cc4654560d932aece8c45e' 
  AND token = 'zSjcBiKQDQz5atEzfs3uPun/jkIMC49B84ZGU0xpsoQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}