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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '274fee70b87ab3d198bd6f4d009e1c4371f87be39721105a19d17870a76ae401' 
  AND token = 'gTN27h+bBvei6huDxFzsNHXSZBVevo3UIq12a1Z3Vi4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}