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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'da43cf621e999b7c166b6dd0c04efc187c92cd2386c73387e9e116c5e833e067' 
  AND token = 'nCvvjD5Vnn0vMTOUl/JYe2RQYWQ3NDu+BDHJiVb9n28=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}